Currently there are many studies on DNA methylation and histone modification (Figure 3)
The G value of + 13.0 kcal/mol for p.Arg106Pro most probably underestimates the effect of the variant because the WT model has the residues 110-112 and 108-112 missing in chains A and B, respectively, and the residues around the variant, including Arg106, have high B-factors, i.e., the position of the side chain does not have high accuracy due, for example, to dynamics
For some patients, especially those in prolonged deficits or intense strength cycles, the shift is subtle but meaningfulbetter training consistency, less metabolic friction, and more usable recovery between workouts
Jiang L, Tu Y, Hu X, Bao A, Chen H, Ma X, Doyle T, Shi H, Cheng Z